SNP Filtering & Harmonization failed to process

[Siddharth_Singh]

In the MetaboAnalyst Causal Analysis workflow, on the SNP Filtering & Harmonization page, clicking Update and then Proceed results in no action, the workflow does not advance, and no error is shown. Persistent for the past few days.

Environment:– Windows 11, Google Chrome

[xia.lab]

Please follow our post guideline

[Siddharth_Singh]

Hi @xia.lab team

Data used

• Exposure: Tartaric acid (selected from the metabolite list)
• Outcome: finn-b-F5_ADHD (selected from the public repository search)

On “SNP Filtering & Harmonization ”, selected the following options:

• LD-based harmonization
• Use clumping to prune SNPs for LD
• Using proxy SNPs when a direct SNP query is absent
• Allele Harmonization
• ⦿ Try to infer the forward strand alleles using allele frequency information
• Remove Pleiotropic SNPs
• ⦿ Exclude SNPs associated with multiple metabolites
• Steiger filtering
• Use steiger filtering
  Click Update (button in the middle of the page).
  Then click Proceed.

- After Update (and/or Proceed), the workflow should run SNP filtering/harmonization and advance to the next step. But no loading/progress indicator or error message is shown.