What is the formula being used by the software for Sample normalization (Normalization by reference feature)?

[Aswin_Chilakala]

Please explain the formula and the calculations being done by the software to normalize the samples based on a feature across the samples.

[jeff.xia]

This is a very simple method used in cases like urine samples (i.e. normalize by creatinine). You can search the MetaboAnalystR GitHub for the R code.