Enrichment Ratio is computed by Hits / Expected, where hits = observed hits; expected = expected hits

what is “expected hits”

Enrichment Ratio is computed by Hits / Expected, where hits = observed hits; expected = expected hits

what is “expected hits”

Enrichment analysis uses null models to compute the theoretical number of hits by random chance (expected hits), and compare this number with what we actually observed based on the data (observed hits).

Assuming you are talking about ORA, the model is hypergeometric model. In some cases, we don’t want to specify a model, we can use permutations to estimate the expected hits.

hi，i am wandering how to calculate “expected hits”,

as I know, expected hits = q.size * (set.num/uniq.count), set.num means “total number in this pathway”, q.size means “the number of metabolites we input”, then what is uniq.count?

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