What is a metabolite set?

A metabolite set can be any externally defined groups of metabolites that has something in common. For example,

  • Metabolites that are involved in the same pathways (SMPDB, KEGG, Biocarta);
  • Metabolites that are changed significantly under the same conditions;
  • Metabolites that are associated with the genomic variations (i.e. single nucleotide polymorphism or SNPs);
  • Metabolites that are located in the same cellular compartments;
  • Other published metabolite signatures, ontology terms, etc.

Please note that you can define your own metabolite set for functional enrichment analysis using MSEA.