What are the differences among the pathway databases in joint-pathway analysis?

There are four different types of pathways prepared for users to integrate and interpret their data.

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All these pathways are based on KEGG database obtained using KEGG REST API. The first two options are for integrative analysis, with the latter option also includes pathways containing only genes (i.e. gene regulatory pathways). The last two options are mainly for users to compare the results based on metabolites only or genes only,