MSEA and QEA for peak intensity table


Can I do quantitative enrichment analysis for untargeted lipidomics data, I mean I won’t have concentrations, it is only normalized peak intensities/intensity ratios for identified/annotated peaks? if no, then what alternative do I have? is it only ORA?

I have seen some papers use this function with peak areas but I am not sure if this is correct or not.

Can you advise please?


I would suggest to read our recent publications on this topic: