Hello Omics Community,

I’m exploring Metabolite Set Enrichment Analysis (MSEA) and have come across terms that I need further clarification on: Statistic Q and Expected Q. I have the following specific questions:

- How is Statistic Q interpreted? In the context of MSEA, what does Statistic Q represent, and how is it used to analyze the data?
- How is Expected Q interpreted? What does Expected Q signify in MSEA, and how is it calculated and applied?
- What is the relationship between Statistic Q and Expected Q? How do these two values relate to each other in MSEA, and what insights can be drawn from their relationship?
- Is the statement “a lower Q-Value indicates significant enrichment” correct? I’ve come across this statement in my research. Can anyone confirm if this interpretation of a lower Q-Value is accurate in the context of MSEA?

I would greatly appreciate any insights, references, or examples that can shed light on these questions.

Thank you for your time and expertise!

Best, ausdreh