How to decided between PCA, PLS-DA, sPLSDA, OrthoPLSDA?

MetaboAnalyst
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I would like to compare the metabolomic data (untargeted) between two different groups.
How can I know what type of analysis I need to perform?
What would be the best option PCA, PLS-DA, sPLSDA, or OrthoPLSDA?

Thank you in advance.

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Hello,
PCA is an unsupervised analysis, while others are supervised based on the class information. There is no absolute definition which one is the best because they are constructed with different algorithm and shows different performance for different data. You can read these papers

  1. Westerhuis, J.A., van Velzen, E.J.J., Hoefsloot, H.C.J. et al. Multivariate paired data analysis: multilevel PLSDA versus OPLSDA. Metabolomics 6 , 119–128 (2010). Multivariate paired data analysis: multilevel PLSDA versus OPLSDA - Metabolomics;
  2. Lê Cao, KA., Boitard, S. & Besse, P. Sparse PLS discriminant analysis: biologically relevant feature selection and graphical displays for multiclass problems. BMC Bioinformatics 12 , 253 (2011). Sparse PLS discriminant analysis: biologically relevant feature selection and graphical displays for multiclass problems | BMC Bioinformatics | Full Text)

to learn more on the difference between them.

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