How are pathway BMDs (pathBMDs) calculated?

Gene set analysis is used to identify significantly overrepresented pathways in the list of geneBMDs. Pathway-level BMDs (pathBMDs) are calculated as the bootstrapped median of the geneBMDs in that pathway. The National Toxicology Program Approach to Genomic Dose-Response Modeling defines the tPOD as the lowest pathBMD.