Yes. For query metabolites, you can test enriched KEGG pathways. For query genes only, you can test enriched Gene Ontologies or pathways (KEGG/Reactome).
There are three steps (please refer to the Fig. below)
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Click the “Reset” icon
in the network tool bar to make sure no nodes are highlighted in the current network
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Highlight nodes based on your interest using one of the three methods:
a) Use the checkboxes in the Node Table on the left; Or
b) Use the free select iconto drag-select nodes directly on the network; Or
c) Entering a list of node IDs to the text box in the “Batch Selection” panel on the right side -
After that, select a functional catergory from the Function Explorer section, make sure the Query option is set to Highlighted Nodes and click the Submit button.