Where do the "Diseases, drugs, and chemicals" interactions come from?

  • The Protein-drug Interactions come from DrugBank, a database that combines manual curation, bioinformatics and cheminformatics data on drugs and drug targets.

  • The Protein-chemical Interactions come from the Comparative Toxicogenomics Database, which contains curated interactions between chemicals and genes from the literature.

  • The Gene-disease Associations come from DisGeNET, which integrates data from expert curated repositories, GWAS studies, multiple species, and the literature.

Note that in the created networks, the added nodes are connected to seed genes but not to each other, and are represented as squares instead of as circles.