ProteoAnalyst offers nine network layout algorithms to help explore the results. The “Compartment layout” put proteins sharing the same cellular compartments within the same rectangular region. Users can adjust the color and node sizes for all proteins within the same compartment
The cellular localization data is derived from the UniProt Knowledgebase (UniProtKB). To facilitate clustering and functional analysis, we map UniProt’s granular location terms to a simplified set of broad functional environments.
Users can inspect the specific granular location and its assigned broad category for any selected protein in the bottom right corner of the interface (see screenshot below). The supported categories include:
- Nucleus
- Cytosol
- Endomembrane
- Mitochondrial & Metabolic Organelles
- Cytoskeleton
- Cell Surface & Adhesion
