What are the main differences between a SNP-metabolite network and a SNP-gene-metabolite network?

In SNP-metabolite network, SNP nodes connect to metabolite nodes with which they have shown significant statistical associations. We have curated significant associations based on study-specific genome-wide cutoff threshold. See Resources page for more details.

To gain functional insights into SNP-metabolite networks, mGWAS-explorer offers SNP-gene-metabolite networks by introducing a new node type (genes) and new edge types (SNP-gene, gene-metabolites) based on SNP annotation and known gene/protein - metabolite relationships (i.e. enzymatic reactions or transporters).